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Digital Health Integration in the US: 4 Layers That Must Align

Amara Okonkwo July 20, 2025
Digital Health Integration in the US: 4 Layers That Must Align

Digital Health Integration in the US: 4 Layers That Must Align

Digital health integrations in US healthcare span four architectural layers. When they align, integrations ship; when they don't, projects stall. Understanding the layers prevents scope confusion.

Layer 1: Data layer

FHIR-based clinical data storage. HAPI, Aidbox, Medplum, commercial EHRs. This is the source-of-truth.

Layer 2: Terminology layer

SNOMED CT, LOINC, RxNorm code systems and their FHIR CodeSystem/ValueSet/ConceptMap representations. Terminology servers manage this layer.

Layer 3: Integration layer

SMART on FHIR launch, Bulk Data `$export`, CDS Hooks. This is where apps meet the data.

Layer 4: Application layer

Clinician-facing UIs, patient portals, analytics dashboards. Consumes data via layer 3.

Alignment failures

Failure Symptom
Data layer without terminology Free-text coded fields, analytics broken
Data layer without integration No third-party ecosystem
Data layer without application Just a data store, no clinician value
Skipping bulk data Analytics stuck at REST speed
Custom auth instead of SMART No third-party apps work

Investment ratio (empirical)

Layer Typical spend %
Data 30-40%
Terminology 10-15%
Integration 20-30%
Application 20-30%

Sites that underinvest in any layer see downstream integrations struggle. The alignment across layers is what makes a deployment feel coherent.

Common misalignment

1. Heavy data layer investment, minimal terminology → quality drift. 2. Heavy application layer, weak integration → third parties can't consume. 3. Custom integration surface → ecosystem fragmentation.

Four layers, aligned investment, coherent delivery.

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